ClearLight Biotechnologies for IHC Multiplex in 3D using CLARITY Tissue Clearing

Techism is pleased to be working closely with ClearLight Biotechnologies for marketing and design as well as website support.

ClearLight Biotechnologies is an early stage startup that is developing a refined biological approach and an automated instrumentation platform based on the CLARITY lipid-clearing technique developed by founder, Karl Deisseroth MD PhD and colleagues at Stanford University. This technique enables the transformation of tissue into a nanoporous, hydrogel-hybridized form that is crosslinked to a three-dimensional network of hydrophilic polymers. The process produces a fully assembled, intact tissue, which is permeable to macromolecules and optically transparent, thus allowing for robust three-dimensional imaging of subcellular components (DNA, RNA and protein) and analysis of heterogeneous cellular interactions within the microenvironment of a tissue. This technology and platform, paired with proprietary 3D image analysis software, will enable more accurate analysis and assessment of normal and diseased tissue.

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